Overview

Welcome to the Interactive Safety Graphics home page. We make open source interactive graphics for monitoring clinical trial safety. Check out a sample graphic along with its paired clinical workflow based on the medical literature, or explorer your own data using the safetyGraphics R package shown below.

Background

The Interactive Safety Graphics (ISG) subteam of the ASA Biopharm-DIA Safety Working Group is an interdisciplinary effort that, amongst other things, seeks to provide a clinical safety workflow for monitoring during clinical development in an open source model. For more details see:

• About Page - learn more about our team’s motivation and see a full list of team members
• Road Map - learn more about our active and planned projects
• Contribution guidelines - learn about how to contribute code to the project

safetyGraphics R Package

The safetyGraphics R package makes it easy for users to evaluate thier own clinical trial safety data in R. The package provides a simple workflow to load lab data from clinical trials (AdAM or SDTM preferred).

To learn more you can:

• See the package on CRAN
• Download the clinical workflow
• Explore the github repo for the package, or read through the package vignettes:
  • Intro to safetyGraphics - Introductory vignette providing the overview of the package.
  • Chart Configuration Vignette - Details about the charting process including technical specifications and step-by-step instructions
  • Cookbook Vignette - A series of examples showing how to initialize the safetyGraphics Shiny app in different scenarios
  • Technical FAQ Vignette - vignette discussing security, validation and other technical issues
• Check out the underlying javascript library used to create the Hepatic Safety Explorer Chart
• Try out a hosted version of the shiny app
• Check out other interactive graphics for safety monitoring. We also wrote a paper about these. Our plan is to add some of them to SafetyGraphics package in future releases.
• Take a look at the technical framework being used to create the chart
• Explore some of our presentations
  • See the poster we presented at RStudio::conf(2019)
  • See the slides or video introducing safetyGraphics v2.0 from R in Pharma 2020