Interactive Visual Kidney Function Data Exploration in Clinical Trials
Summary
The ASA Biopharmaceutical Working Group’s taskforce on Interactive Safety Graphics has developed an open-source, interactive graphical tool to allow safety professionals to easily explore clinical trial laboratory data in order to identify instances of acute declines in renal function. “Drill down” capabilities provide a means to evaluate subject level data. The tool is accompanied by a comprehensive “clinical workflow” that guides the user through a series of evaluations each with a textual discussion regarding the goal of the evaluation step and the relevance of any findings with references to the supporting nephrology literature.
Installation
nepExplorer is not available on CRAN yet. You can install the package from GitHub: devtools::install_github('safetyGraphics/nepExplorer', ref = 'master')
Using the App
nepExplorer was built using the safetyGraphics framework and uses a settings object to map fields from input data sets to chart aesthetics and configuration options. A demo of the app is available here.
The {nepExplorer} package can be used in two ways:
As a standalone app using create_nepexplorer_app(). To run the standalone app with example data and default mappings simply use:
create_nepexplorer_app(). If you need to customize the arguments for your own data, see the standalone example here.As a shiny module within a safetyGraphics application. See safetyGraphics example here. The unit conversion functions included in this code are specific to the safetyData datasets. Conversion factors will vary based on your data. It’s recommended to use the conversion units established by your own sponsor lab conversions.
Data domain, field, and format expectations are detailed in the Data and Settings Guidelines Wiki.
If it’s your first time configuring and running nepExplorer, check out the Getting Started Vignette.